Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates

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Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates.

OBJECTIVES Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and staphylococci. The purpose of this study is to extend this observation to mycobacteria and to quantify mutation rates. METHODS The mutation rate in Myco...

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this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...

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Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin.

OBJECTIVES To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis. METHODS Genome-wide expression profiling followed by quantitative RT (qRT)-PCR was used to study the effect of ciprofloxacin on M. tuberculosis gene expression. RESULTS Microarray analysis showed that 16/110 genes involved...

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Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.

OBJECTIVES To investigate the effect of subinhibitory concentrations of ciprofloxacin, streptomycin, trimethoprim, ampicillin and erythromycin on mutation frequency in Streptococcus pneumoniae. METHODS Frequency of mutation to rifampicin resistance was determined in three clinical isolates grown with or without antibiotic treatment. dinB was analysed using PCR and DNA sequence determination. ...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2005

ISSN: 1460-2091,0305-7453

DOI: 10.1093/jac/dki191