Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates
نویسندگان
چکیده
منابع مشابه
Effect of subinhibitory concentrations of ciprofloxacin on Mycobacterium fortuitum mutation rates.
OBJECTIVES Fluoroquinolones have found a place in the management of mycobacterial diseases including tuberculosis. It has been previously shown that subinhibitory concentrations of quinolones increase the mutation rate in Escherichia coli and staphylococci. The purpose of this study is to extend this observation to mycobacteria and to quantify mutation rates. METHODS The mutation rate in Myco...
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15 صفحه اولMycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin.
OBJECTIVES To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis. METHODS Genome-wide expression profiling followed by quantitative RT (qRT)-PCR was used to study the effect of ciprofloxacin on M. tuberculosis gene expression. RESULTS Microarray analysis showed that 16/110 genes involved...
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15 صفحه اولEffect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.
OBJECTIVES To investigate the effect of subinhibitory concentrations of ciprofloxacin, streptomycin, trimethoprim, ampicillin and erythromycin on mutation frequency in Streptococcus pneumoniae. METHODS Frequency of mutation to rifampicin resistance was determined in three clinical isolates grown with or without antibiotic treatment. dinB was analysed using PCR and DNA sequence determination. ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2005
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dki191